The list goes on and on..
Maybe the biggest challenge is the loss of agency. You have probably experienced this (as I have), or witnessed this in others: when your days are directed by the demands of something external, you can tend to respond by giving up your will and sovereignty over your own life. In other words, you expect work-life balance to be conditional on something like your rota and are unwilling or unable to channel your energy to dealing with any of the above challenges you might face.
What are its consequences?